HIV-serodiscordant male couples face unique challenges in care and prevention, often exacerbated by stigma. This study evaluates the efficacy of the We-INtervention, a three-session, relationship-focused program designed to leverage dyadic resources to improve health and well-being among Chinese couples.

Building on a successful pilot trial that demonstrated feasibility and preliminary efficacy, this randomized controlled trial (RCT) examines the intervention's impact on perceived stigma, quality of life, and HIV-related behavioral outcomes. Participants are randomized into either the We-INtervention arm or a control arm receiving health pamphlets.

Data collection involves quantitative assessments at four time points, including pre-intervention, post-intervention, and at 1- and 3-month follow-ups, complemented by qualitative exit interviews. By focusing on couple-centric, culturally sensitive care, this research aims to reduce health inequalities and provide a scalable model for integrating relational support into existing medical care frameworks for HIV-affected populations.