Clinical and health psychologists in our department have been conducting cutting-edge research projects on adjustment to life-threatening illnesses (e.g., cancer, coronary heart disease, HIV), traumas (e.g., SARS and COVID-19 pandemics, natural disasters), losses (e.g., grief), acculturation (e.g., migration), and challenges (e.g., aging, correctional services). Focusing on clinical innovation and resilience, we have generated new knowledge in this field by designing and validating assessment tools, examining promotive and protective factors, investigating psychosocial and physiological mechanisms, and studying the resilience and transformation processes. Moreover, we have developed intervention and therapeutic programs to promote adaptive psychological functioning and enhance resilience among various populations. The ultimate goal of their research is to arrive at a better understanding of the complexity of how risk and resilience factors are translated into mental health outcomes. These research findings have contributed to healthcare and social service development for better life and wellbeing.