This research cluster emphasizes advancing empirical research on dual focuses including substance use patterns and mental wellness of people in society. Its strategic aims are developing innovative prevention and intervention strategies to expand understanding of youth substance use patterns and enhance mental wellbeing of adolescents and older adults. The cluster is pioneering in its use of expressive arts, mindfulnessbased relapse prevention, meaning-centered approach and faith-based treatment to substance addiction in Hong Kong. In response to the special needs in the COVID-19 pandemic and recent global technological developments, the cluster has also developed an online platform, which combines mindfulness and CBT interventions, providing counselling support for adolescents and older adults with depression and anxiety. Beneficiaries include over 3,000 students, parents and teachers, 2,000 individuals with drug abuse issues, and 3,000 other participants who have benefited from our online platform that targets mental health.